Novel method for depth-resolved brain functional imaging by time-domain NIRS

摘要

A novel approach to improve depth selectivity based on time-domain contrast functions is presented. The method was tested with Monte Carlo simulations showing sensitivity to absorption changes of deep inclusions and improved rejection of superficial effects. Preliminary in-vivo measurements were performed on healthy volunteer during a Valsalva maneuver and during finger tapping discriminating brain cortex activation from hemodynamic changes associated to systemic effects in the scalp.