Mathematical Modeling on Immunopathogenesis in Chronic Plaque of Psoriasis: A Theoretical Study

摘要

Psoriasis is a chronic inflammatory human skin disorder characterized by T-cell mediated hyperproliferation of Keratinocytes. The exact nature of the triggering agent of psoriasis is not yet known. Cell biological findings on the disease revealed that Helper T-cells in the human blood as well as Dendritic Cells play an important role in inflicting the disease. Further, clinical research suggests that excessive generation of nitric oxide, through a complex chain of bio-chemical events, is causal to the scaliness of psoriatic plaques on human skin. We propose a mathematical model involving the densities of immune cells and Keratinocytes where proliferation of Keratinocytes together with excessive nitric oxide production is precursor to the psoriatic lesions. The model is studied both analytically and numerically. Results are observed to be consistent with the cell biological and clinical findings.