RECENT PROGRESS IN MIXED SOLVENT SOLUBILITY ESTIMATION Solute-free nonideality

摘要

The solubility of sparingly soluble solid drugs in liquid solvents has undergone extensive study in the past. The importance of proper description of solid/liquid equilibrium has facilitated the need for a more fundamental approach to the modeling framework. The complexity of the solid/liquid equilibrium increases significantly when more than one liquid solvent is present. Models in the literature are frequently empirical in nature and this usually makes the reason(s) for their failure unclear. In order to increase the solubility of a solid in a solvent (e.g. water) an organic solvent is usually added to increase certain properties (e.g. hydrophobicity). The cosolvency effect associated with this solvent blending is frequently sought through a trial-and-error approach, requiring substantial laboratory efforts.