Allergen potential of non-prolamin seed proteins in Brachypodium distachyon

摘要

Prolamin proteins are considered key players in the development of wheat-related health problems, such as celiac disease or wheat allergy. However, there are further protein families that cause allergic responses. The relatively small number of expressed wheat seed proteins reported in the protein databases makes it difficult to get a complete overview of the allergome of wheat seed. Whole genome sequencing projects carried out on cereals such as wheat and barley will facilitate an understanding of the complex genetic effects of cereal allergies. Brachyvodium distachyon serves as the evolutionary closest sequenced genome for the Triticene. To better understand the potential detrimental effects of different seed proteins, an in-silico analysis was carried out using publicly available epitope databases and Brachyvodium distachyon genome sequence data. This study summarizes our results in identifying potentially harmful non-prolamin proteins that may cause either celiac disease or wheat allergy-related symptoms.