The Optimization of Medicine Formulation Using Mixture Experiments

摘要

Medicine is composed by several components. The quality characteristic of medicine usually depends on the proportions of its components. The research studied the component proportions of medicine SIBELIUM capsule without considering its mixture amount and other process factors. Design points of symmetric-simplex design and design points generated by XVERT Algorithm are both discussed in the research. There are two quality characteristics of the medicine being considered. After collecting the data of the two designs and searched for their corresponding prediction equations, the two quality characteristics are optimized using desirability function. The research found the optimal component proportions of the two designs are pretty close and the optimal values of the two quality characteristics are almost the same.