The Relativity between Cytokines and Psoriasis and the Influence on Its Variation Induced by ILLLI

摘要

Objective: To explore the relativity between cytokines such as IL-8,TNF-α,VEGF and psoriasis and the influence on its variation by ILLLI.Methods:47 patients with psoriasis were divided into 5 groups ,treated with ILLLI( 1h per day , a course of treatment is 10 days),observed the variation of IL-8,TNF-a and VEGF in peripheral blood of patients with psoriasis between pre and post treatment and compared with the control. Results: 1. In each case of psoriasis, the concentration of IL-8 in blood was significantly higher than that of control group. After treatment, the concentrations of A group, B group and C group were decreased significantly, which were close to the control. The related statistical analysis showed significant difference. Among them, A group decreased most significantly; Although there is no significant difference in concentration of IL-8 of D group and E group between pre and post treatment, the trend of them became to keep decreasing. In each case of psoriasis, the concentration of TNF-a in blood was much lower than that of control group. The concentration of TNF-a in A、C、D group increased significantly as compared with pre-irradiation except that in E group. In cases, the concentrations of VEGF in blood were much higher than that of control group. In each group, there was no difference in VEGF concentration between pre and post irradiation. Conclusions: The decrease of IL-8 induced by ILLLI might be related with its immunosuppressive function. It suppressed the activity of CD4+T cell which could secrete a great deal of IL-8 and play an important role to the tache of psoriasis onset. So in the psoriasis patients who were treated with ILLLI, the production of TNF-a could be suppressed. In patients, the increasing of VEGF might be related with the increasing of IL-8. There was no difference of it between pre and post ILLLI treatment might because VEGF was not the action target of ILLLI.