Acid Cleavable Multifunctional Prodrugs Derived from Dendritic Polyglycerol

摘要

The diversified pathophysiological scenarios for many different disease conditions continually call for innovative and novel therapeutic approaches. In line with conventional treatment strategies, the application of nanotechnology in medicine and pharmaceuticals is a rapidly moving field that is gaining fast acceptance and recognition as an independent area of research and scientific endeavor. In recent years, a number of studies have been reported using dendritic polymers for biomedical applications due to their unique properties which significantly differ from their linear counterparts. Dendritic molecules such as polyamidoamine, polylysine, polyester, polyglycerol, and triazines dendrimers have been introduced for biomedical applications to molecularly amplify or multiply pathopharmacological effects or to create extremely high local concentrations of drugs, molecular labels, or probe moieties.