OptMAVEn: De novo Design of Antibody Variable Regions(PPT)

摘要

A Develop OptMAVEn for De novo design of antibody variable domains B OptMAVEn simulates in silico the in vivo steps of antibody generation and evolution 1. Antigen positioning 2. Assemble antibodies by V-D-J recombination using MAPs database 3. Computational affinity maturation and humanization by IPRO C Application of OptMAVEn for designing antibodies against HIV, influenza and Ebola viruses.