Molecular dynamics simulation of Plantaricin E/F, a class IIb bacteriocin

摘要

Pathogens that are resistant to single or multiple antibiotics emerge at a pace that exceeds the development of new drugs. This trend renders the discovery of new antibacterial therapies, such as antimicrobial peptides (AMPs), crucial. In order to establish AMPs as new antibiotic agents a detailed understanding of their mechanism of action is imperative. Molecular dynamics (MD) simulation, which makes use of an atomistic resolution model of the system under investigation, is an invaluable tool for providing insight into the mechanism of action of AMPs.