PRODRUG LIPID FORMING HIGH DRUG LOADING MULTIFUNCTIONAL NANOCAPSULES

摘要

Nanosized drug carriers[1-3] have been extensively explored in drug delivery for cancer chemotherapy. They can greatly enhance the water-solubility and stability of otherwise water-insoluble and unstable drugs, prolong their circulation in blood compartments, target cancerous tissues by passive accumulation via the enhanced permeability and retention effect and by targeting groups. Therefore, by increasing drug bioavailability at sites of action and overcoming drug resistance, drugs in these carriers have shown therapeutic advantages including higher efficacy against resistant tumors and fewer side effects than free drugs.