Nanocapsules comprising (semi-) liquid lipid core and solid lipid shell, prepared by phase inversion methods, useful for administration of lipophilic or hydrophilic drugs by injection, orally or intranasally

摘要

The invention concerns nanocapsules, in particular with an average size less than 50 nm, consisting of an essentially lipid core liquid or semiliquid at room temperature, coated with an essentially lipid film solid at room temperature having a thickness of 2-10 nm. The invention also concerns a method for preparing same which consists in producing a reverse phase of an aqueous emulsion brought about by several temperature raising and lowering cycles. Said lipid nanocapsules are particularly designed for producing a medicine.