Many biotechnological applications require the immobilization of proteins and enzymes to solid surfaces.1 Colloidal particles of a few hundred nanometers in diameter are well-suited for this purpose since they provide large surfaces. Leaching out of immobilized enzymes is to be avoided during catalysis, which demands for a strong binding to the support. The adsorption to solid substrates leads to high adsorption energies. This often goes along with a deformation or flattening of the native enzyme and thus limits its activity.
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