THE ROLE OF THE CRP/CAMP PROTEIN COMPLEX IN DNA TRANSCRIPTION

摘要

DNA molecules direct the synthesis of specific RNA and protein molecules. In the early stages of protein synthesis, specific regions of the DNA (genes) are copied into short strands of RNA that retain all of the genetic information of the DNA sequence from which they were copied. The process by which RNA molecules are synthesized from the coding regions of DNA is known as DNA transcription. The RNA polymerase enzyme, whose function is to make a RNA copy of a DNA sequence, catalyzes the synthesis of these RNA molecules. The amount of RNA made from a particular region of DNA is controlled by gene regulatory proteins that bind to specific sites on DNA close to the coding sequences of a gene. In this highlight we describe experiments addressing how a particular gene regulatory protein controls RNA transcription from DNA.