Protein Tyrosine Phosphatases IB Inhibitors from Traditional Chinese Medicine

摘要

In our research for natural products with antidiabetes activity, we screened our extract bank for inhibitors of PTP1B enzyme and found that some fractions from ethanol extract of Traditional Chinese Medicine showed strong inhibitory bioactivity against PTP1B enzyme. Using the PTP1B enzyme bioassay as a guide, chromatography of the fractions afforded several potential PTP1B inhibitors. Modification of oleanolic acid yielded novel more potent and higher selective PTP1B inhibitors.