Structure-Based Optimization of Benzoic Acids as Inhibitors of Protein Tyrosine Phosphatase IB and Low Molecular Weight Protein Tyrosine Phosphatase

摘要

Protein tyrosine phosphorylation plays a key role in the regulation of signal transduction, which underlies many fundamental cellular functions. The cellular level of protein tyrosine phosphorylation is the result of the concerted activities of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). PTPs comprise a large family of more than 100 enzymes, which can function both as positive and negative modulators in specific signaling pathways, thus playing complex and crucial physiological roles in most mammalian cells.