Calcium phosphate composite organogel was synthesized from a mixture of sorbitan monopalmitate as emulsifier and castor oil as oil phase at 60 °C to establish emulsion system with calcium chloride and di-sodium hydrogen phosphate aqueous solution as water phase.The heated mixture was cooled at room temperature to form organogel.The prepared organogels were investigated by thermogravimetric analysis (TGA),scanning electron microscope (SEM),transmission electron microscope (TEM) and cytotoxicity test.The prepared organogels of 4:3 and 1:1 in oil/water content ratio were white and gritty in nature,which resulted in calcium phosphate nanoparticles with spherical shape of 1.3 to 1.9 urn and 1.2 to 2.3 urn,respectively.They were able to successfully occlude into dentine tubules within 1 day.In addition,the prepared organogels were found to have acceptable toxicity level for daily human use with high concentration up to 1600 μg/ml.Hence,these organogels showed the promising results to be developed as an effective dentine occlusion material in relieving of dentin hypersensitivity.
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