We studied high-performance ion-selective field-effect transistors (ISFETs) to detect human salivary stress-markercandidates using direct potentiometry. For acute stress monitoring, we investigated various kinds of sensor materials,designed nitrate-sensing materials, designed plasticizers and biocompatible polymers for salivary nitrate ISFETs.We prepared prototype of silicon based FET nitrate checker using specially ordered FET mV checker. The prototype ofnitrate ISFETs showed almost the theoretical Nernst response with a response time of less than 10 seconds. As weapplied whole human saliva using direct potentiometry, we obtained excellent relationship with conventional ionchromatography.We successfully demonstrated several acute stress tasks for healthy volunteers using wearable heartrate monitor and prototype of salivary nitrate checkers based on NO_3~--ISFETs.We also discussed high-performance organic transistor based FET (OFET) biosensors for stress monitoring usingextended-gate type configuration towards stress monitoring.
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