BROADENING THE SUBSTRATE SCOPE OF STRICTOSIDINE SYNTHASES BY SITE-DIRECTED MUTAGENESIS

摘要

The condensation of β-arylethylamines with carbonyl compounds (Pictet-Spengler reaction) is employed in the synthesis of tetrahydro-β-carboline and isoquinoline scaffolds which are common motifs in many naturally occurring alkaloids. These compounds exhibit a range of biological activities and are thus interesting targets for organic synthesis and medicinal chemistry.