ENZYMATIC SYNTHESIS OF GLUCAN DENDRIMER FOR PHARMACEUTICAL APPLICATIONS

摘要

Bio-macromolecules (e.g. protein, peptide, antibody DNA or RNA) present in our bodies are now widely utilized in pharmaceuticals. Carbohydrates, on the other hand, have been receiving increasing attention as drug candidates, but the pharmaceutical usage of carbohydrates is limited to few glycosaminoglycans (e.g. heparin, hyaluronan or chondroitin sulfate), which are all endogenous polysaccharides. Glycogen is another polysaccharide present in our bodies as energy reserves, and its application for pharmaceuticals is not evident either.