Formulation and Surface Properties of Bio-Basecl Polymer Films for Pharmaceutical Applications

摘要

Hydroxypropyl methylcellulose (HPMC) constitutes one of the most dedicated polymers used in the production of film coatings for pharmaceutical applications (capsules, tablets ...). In order to control the surface properties (adhesion, friction, wear) of HPMC films, additives are frequently incorporated during film formulation: these are in most cases hydrophobic lubricant (like fatty acids) or hydrophilic plasticizer. Hydrophilic plasticizer like polyethylene glycol (PEG) will determine the diffusion properties of water through the film and thus drag release but also its deformability as well as its surface softness. The main objective is to use dedicated analytical tools to access HPMC formulated film surface characteristics in terms of structuration, surface morphologies, surface phase separation, wettability, nano-adhesion and nano-friction properties. At nanoscale, Atomic Force Microscopy (AFM) in contact mode and in friction mode (FFM) is a powerful tool for studying nano-adhesion and nano-friction. The presented paper underlines the strong dependence of film surface properties on additive nature and concentration. It also shows that first the HPMC-additive compatibility seems to be an interesting factor behind the variation of surface properties of HPMC formulated films, and second that formulation is an effective way to tune surface properties of HPMC biopolymer films.