SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL (TRIAZOLYL)METHYL AMIDE-LINKED PSEUDODISSACARIDE NUCLEOSIDES AS POTENTIAL GLYCOSYLTRANSFERASE INHIBITORS

摘要

Glycosylation is the most important post-translational modification occurring in proteins and other biomolecules, being involved in many cell processes such as cell-cell interactions and immune response [1]. Glycosyltransferases are enzymes responsible for the formation of glycans and glycoconjugates. Changes in glycosylation patterns on glycoproteins and other glycoconjugates occur in cancer and is considered a hallmark of this disease [2]. Therefore, inhibition of glycosyltransferases is a promising therapeutic strategy in anticancer therapy [3].