Chitosan is a linear biopolymer with many interesting properties like biocompatibility, non-toxicity, biodegradability, including antimicrobial activity. In recent years, it has been shown that chemical modification of chitosan can lead to significant improvement of its antimicrobial effect. The aim of this study was therefore, to selectively modify the amino group of chitosan by various cationic and lipophilic moieties to obtain derivatives having improved antimicrobial activity and aqueous solubility than chitosan itself. The aim was also to investigate the effect of average molecular weight (Mw) of chitosan on their antimicrobial properties.
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