GLYCOSYLATION AS A STRATEGY FOR DETOXIFICATION OF AMINOGLYCOSIDE ANTIBIOTICS

摘要

Aminoglycoside antibiotics (AGs) perturb with the fidelity of bacterial translation by binding to the A-site decoding region of the prokaryotic ribosome. These antibiotics are highly effective in treating severe pulmonary infections, especially those frequently occurring in cystic fibrosis patients. Unfortunately however, the antibacterial efficacy of AGs is overshadowed by the side effects that accompany systemic treatment with these antibiotics. Development of strategies to overcome this major obstacle is therefore of high priority.