STEREOSELECTIVE SYNTHESIS OF p-MODIFIED α-GLYCOSYL PHOSPHATES BY THE OXAZAPHOSPHOLIDINE APPROACH

摘要

α-Glycosyl phosphate derivatives are widely known as constituents of biomolecules. They have repeating units of phosphoglycans and many of them are considered to be important factors in several biophenomena. Therefore, several kinds of α-glycosyl phosphate analogs have been synthesized in order to clarify their biomechanisms and apply to the drug development. Among them, we focused on the "P-modified analogs" because the phosphodiester moiety is considered to be of chemical and biological importance. Such derivatives have a chiral center at the intersugar phosphorus atom, whose stereocontrolled synthesis hasn't been accomplished yet.