Synthesis of inhibitors of the heptose biosynthetic pathway for the discovery of Antivirulence and Antibacterial Agents

摘要

Our laboratory is interested in the mechanistic and inhibition studies of essential enzymes involved in the bacterial cell wall biosynthesis of important human pathogens such as Mycobacterium tuberculosis. Within this context, we have developed novel synthetic methodologies for the preparation of fluorinated exo-glycals and 2-fluoro-glycosides with high anomeric selectivity.