HIGH AFFINITY EPITOPES OF ANTI-MUCIN 1 ANTIBODY DEVELOPED BY THE SYNERGY OF COMBINATORIAL CHEMISTRY AND MICROARRAY

摘要

Mucin 1 (MUC1) is a membrane bound glycoprotein expressed in epithelial tissues and overexpress on several tumor tissues. The MUC1 extracellular region contains a high repetitive tandem repeat domain of 20 amino acids, with the potential of several O-glycosylations sites on Ser and Thr. This glycoprotein is underglycosylated in several cancer patients, making MUC1 a potential target for diagnosis and immunotherapy.