REVERSIBLE AND EFFICIENT INHIBITION OF UDP-GALACTOSE MUTASE BY ELECTROPHILIC, CONSTRAINED AND UNSATURATED UDP-GALACTOSES

摘要

In the fight against Multi-drugs resistant strains of Mycobacterium tuberculosis, novel therapeutic targets such as UDP-Galactopyranose Mutase (UGM) have been identified. This enzyme, absent in mammals, interconverts UDP-Galactopyranose (UDP-Galp) to UDP-Galactofuranose (UDP-Galf). The UDP-galf is the activated precursor of galactofuranose residues that are essential components of the cell wall biosynthesis of bacteria like Klebselliae Pneumoniae or Mycobacterium Tuberculosis.