Screening Methodology for Discovery of Inhibitory Peptides against Pathogenic Proteins using a Plug-plug Affinity Capillary Electrophoresis Technique

摘要

Conventional capillary electrophoresis has been improved by the introduction of the "plug-plug" technique to screen peptide ligands binding to a target protein. With this technique, three peptides possessing considerable affinities for calmodulin were identified from a Glu-C digest of bovine serum albumin.