Virtual spatial navigation tests based on animal research - spatial cognition deficit in first episodes of schizophrenia

摘要

The impairment of cognitive functions represents a characteristic manifestation in schizophrenia. Animal models of schizophrenia demonstrated behavioural changes in several spatial tasks. In order to assess spatial abilities in schizophrenia using methods applicable in comparative research, we designed two virtual tasks inspired by animal research: the Morris water maze and the Carousel maze. The tested subject is required to navigate toward several hidden goal positions placed on the floor of an enclosed stable arena or a rotating arena. Data obtained in a group of schizophrenia patients show cognitive impairment in both newly-developed virtual tasks comparing to matched healthy volunteers.