Self-Assembled Plasmonic Sensor Platforms: a Promising Approach for Monitoring, Enzymatic Degradation of Thin Gelatin Layers

摘要

Plasmonic sensors based on periodic hole arrays in metallic films are investigated for monitoring enzymatic degradation of extracellular matrix. Sensors are fabricated using a bottom-up strategy in which soft colloidal lithography is combined with chemical gold film deposition. The resulting plasmonic sensors show extraordinary transmission of light supported by surface plasmon polaritons. These are highly sensitive to refractive index changes in close proximity to the sensor surface and are utilized for the quantitative detection of extracellular matrix degradation.