A proteomics profile associated with neoadjuvantchemotherapy response in triple-negative breast cancer

摘要

Microdissectionresults in enrichment of tumor epithelial cell proteins with a high repeatability (fig. 2) Modified Student's t-test increases power for heterogeneous diseases (fig. 3) Several differentially abundant proteins were identified that have previously been suggested to be involved in chemotherapy response (fig. 4) Validation will be performed using mass spectrometry based proteomics on an independent patient cohort Selected proteins will additionally be validated on tissue microarrays.