Development and validation for the determination of (E)-(Z)-vitamin K1 isomers in human plasma by LC-MS/MS

机译：LC-MS / MS在人血浆中测定（e） - （Z） - vitamin K1异构体的显影和验证

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This is reliable and rugged LC-MS/MS method for separation and quantitation of vitamin K1 isomer in human K_2EDTA plasma. The advantages of the method are a shorter run time and a reduction in mobile phase solvents. This assay was used to support a two-way crossover bioequivalence study of a single 5 mg dose.

机译：这是可靠且坚固的LC-MS / MS / MS方法，用于分离和定量人K_2EDTA等离子体中的维生素K1异构体。该方法的优点是更短的运行时间和流动相溶剂的减少。该测定用于支持单个5mg剂量的双向交叉生物等效性研究。

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《American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics》|2013年||共1页
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Jingguo Hou; Marie Prybyla; Laura Binneboese; Melvin Tan; Xiaodong Zhu; Thomas Horvath; Michael Sullivan; Edward Wells; Steve Unger;
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中图分类 TB994.5-53;
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Development and validation for the determination of (E)-(Z)-vitamin K1 isomers in human plasma by LC-MS/MS

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