Data-Independent Acquisition with Ion Mobility (HDMS~E) for Analysis of the Mouse Synaptosome Proteome

摘要

The proteins detected and quantified demonstrate feasibility for the study of synaptosomes/synaptic densities; a critical area of neuroproteomics. Comprehensive analyses of the proteome from the mouse Synaptosome with MS~E-IMS Synapses are key structures involved in neurotransmission and neuroplasticity in the central nervous system. Synaptic proteomics is expected to help define synaptic pathology in schizophrenia, autism, Alzheimer's disease and drug abuse. Large scale profiling of the proteome of the mouse synaptosome was performed with data-independent acquisition and ion-mobility (HDMSE) (Fig. 1).