High Speed TOF-MS for GC and GCxGC Endocrine Disrupting Compounds Characterization in Biological Samples for Environmental Risk Factors Assessment

摘要

TOF-MS is delivering valuable analytical information for more reliable target identification at lower concentration compared to single quadrupole working in SIM mode. To minimize the matrix effect on sensitivity, the GC×GC approach is providing the highest degree of chromatographic separation capability, improving the LOD and maintaining good mass spectra quality at lower concentration level. Preliminary results for unknown samples of human tissues, confirmed a better detectability by using GC×GC-TOFMS, with the identification and quantitation of contaminants not visible with GC-qMS approach. Mass spectra information will be of primary importance for possible further post-investigation of samples for different targe and untargeted contaminants.