Dual Stressor Effects On Relative Protein Levels In Neurospora crassa Strains Measured by iTRAQ Technology

摘要

1. Relative protein level changes in os-2 Mutant vs Wild Type provided insight to os-2 survival; 2. Oxidative respiration may be important to survival under dual stress; 3. Mitochondial transporters, by permeabilizing the membrane, may be acting as uncouplers of electron transport from ATP synthesis; 4. Deficiencies in anti-oxidants typically induced by stress may promote alternative stratagems for survival, such as uncoupling of the mitochondrial respiratory system; 5. Survival stratagem may involve the liberation and acquisition of iron and sulfur for incorporation in antioxidant enzymes and other iron- and sulfur-containing essential enzymes that are adversely affected by ROS.