Functional Proteomics Establishes the Interaction of SIRT7 with Chromatin Remodeling Complexes and Expands its Role in RNA Pol I Transcription.

摘要

1. Working model: SIRT7 forms a complex with RNA Pol I complex along r-DNA repeats. 2. Knockdown of SIRT7 leads to down-regulation of Pol I complex and reduced rDNA transcription.