In-source fragmentation of FAIMS-selected ions in combination with time-of-flight mass spectrometry

摘要

FAIMS has been combined with MS and LC-MS for the selective transmission of pre-selected ions prior to CID within the MS source. Transmission of selected peptide ions from a mixture enhances the detection of characteristic fragment ions, facilitating peptide identification. The tandem FAIMS-CID-MS approach has been shown to resolve isobaric species sufficiently close in m/z value that they could not be resolved by low resolution mass-selection in a quadrupole mass analyzer in conventional MS/MS analysis giving increased confidence in the structural elucidation of molecules.