NETD provides the ability to generate sufficient cross-ring cleavages for location of sites of sulfation while FT-ICR provides the mass accuracy and resolving power necessary to confidently assign the large number of product ions distributed in a narrow m/z window. Although slight differences are observed when EDD and NETD products are compared due to the lack of electronic excitation products, NETD presents a pathway to apply electron-based ion activation to online-chromatographic separation as it is not limited to longer time scales as is EDD.
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