Protein differences associated with human papilloma virus status in oropharyngeal squamous cell carcinoma (OSCC)

摘要

Comparison HPV+vs. HPV-OSCCs Proteomic differences according to HPV status are readily detectable in OSCC. Differential proteins include those involved in differentiation, DNA replication initiation and tissue development. Enrichment analysis for targets of transcription factors indicated overexpression of E2F transcription factor (E2F) in HPV+ OSCCs. Verification by LC-MRM-MS/MS 110 proteins for quantitative verification were selected to distinguish HPV+ and HPV- OSCCs, analysis confirmed the magnitude and direction of protein expression differences in the analyzed set.