16S RRNA SALIVA ANALYSIS UNVEILS MICROBIOME BIOMONITORS LINKED TO HUMAN PAPILLOMA VIRUS AND OROPHARYNGEAL SQUAMOUS CELL CARCINOMA

摘要

The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful in the diagnosis and treatment of head and neck squamous cell carcinoma. As described herein, and particularly in reference to the figures, the present inventors have discovered that OTUs and several microbial communities at different taxonomic levels discriminates HNSCC from normal control samples, HPV+ and HPV− samples and pre- vs. post-surgical treatment samples. Appropriate diagnostic and treatment strategies can be employed based on the identification of the microbiota in patients' saliva.