Toward Routine Dried Blood Spot (DBS) LC-MS/MS Bioanalysis to Support Drug Discovery and Development

摘要

In the last decade, numerous works on the identification and quantification of Se compounds in natural products were published. Most of these studies were based on a synergie approach, the parallel use of molecular and elemental mass spectrometry, and focused on selenoproteins, selenoamino acids (SeMet, SeCys) and low molecular weight selnometabolites (e.g., Seadenosyl-Se-Met, Se-MetSeCys).