Keloids are formed during pathological healing of wounds. This is because fibroblasts involved in wound healing generate forces that continuously exert traction on elements of the extracellular matrix, especially collagen as they adhere in order to facilitate their migration. During this process, the collagen network is deformed and may become aligned. This seems to guide 3D migration causing cells to move bi-directionally along an axis of the aligned collagen fibers. This may result in non-uniform cell distribution.
展开▼
