Osteosarcoma (OSA) is the most common bone tumor in dogs and roughly 80% of OSA tumors arise in the appendicular skeleton of large breed dogs. The majority of patients experience lung metastasis following tumor removal and chemotherapy while a minority remains disease-free for six months or longer. Consequently, the ability to characterize primary OSA for its metastatic potential and chemotherapy resistance would substantially improve the ability to prevent or treat metastatic disease.
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