Identification of key biomarkers and functional pathways in osteosarcomas with lung metastasis

摘要

Osteosarcomais the mostcommonmalignant bonetumor thatmainly originates fromthetubular long bones with uneven crowd distribution and high prevalencein children and adolescents. [1–3] As reported, osteosarcomais proneto develop localinfiltration and distantmetastasis. [4] The mostcommonmetastatic organ is lung, with an incidence ofapproximately 40%to 50%. [5] In recent years, dueto the development ofsurgical techniques, multidrug systemchemotherapy, preciseradiotherapy,and immunotherapy, significant progress has beenmadein thetreatment of osteosarcoma. However,evenwith aggressivetreatment, the prognosis of patients with lungmetastasis remains poor, with a 5-year survivalrate of only 20%to 30%. [3,6,7] Therefore, it isessentialto understand the precise molecular mechanisms involved in lungmetastasis of osteosarcomaand thus develop effective diagnosticand therapeuticstrategies.