FALLAXIN: OPTIMIZATION OF CLEAVAGE CONDITIONS FOLLOWING SOLID-PHASE SYNTHESIS

摘要

The antibacterial peptide amide "fallaxin", GWDILKGAAKDIAGHLASKVMNKL-NH2, was recently isolated from the West-Indian mountain chicken frog "leptodactylus fallax". Fallaxin has been shown to inhibit the growth of the Gram-negative bacteria E. coli, P.aeruginosa, E.cloacae, K. pneumoniae with relatively low potency (MIC ≥20 mM). Fallaxin shows almost no toxicity towards erythrocytes with a hemolytic activity of HC_(50)>200 mM and is therefore a promising candidate for a structure-activity study.