SYNTHESIS AND BIOLOGICAL ACTIVITY OF AMINO ACID ESTER PRODRUGS OF ACYCLOVIR

摘要

Acyclovir, 9-[(2-hydroxyethoxy)methyl]guanine (ACV) is an acyclic guanine nucleoside analogue that is widely used clinically as an antiherpetic agent. Its limited absorption (15% - 20%) in humans after oral administration prompted the search for prodrugs. A possible way to increase the bioavailability is by modifying the known antiviral drugs with various amino acids.