SYNTHESIS AND BIOLOGICAL EVALUATION OF SELECTED INSECT MYOTROPIC PEPTIDES

摘要

Symbols and Special Characters Symbols and Special CharactersTo add a symbol to the paper body: Position the mouse-cursor where you wish to insert the symbol Click on the the symbol you would like to add In the last decade a number of insect peptides, structurally related to neuropeptide FMRF-amide has been identified. These peptides share the conserved X~1X~2RF-amide (where X~1 = R or F and X~2 = L) sequence at their C-terminal ends. Among them two peptides, Led-NPF-1 (ARGPQLRLRFamide) and Led-NPF-2 (APSLRLRF-amide) were isolated from the brain of Lepitonotarsa decemlineata as well as Mas-MT-I, II and III (pEDWHSFLRF-amide, GNSFLRF-amide, DPSFLRF-amide) which originated from the brain of Manduca sexta . The object of our investigation was synthesis of two groups of peptides. There are: 1/ Led-NPF-1 (I), Led NPF-2 (II) and its 14