The major histocompatibility complex (MHC) has a crucial role to initiate the immune response via the binding of the peptide fragments (epitopes) of foreign antigens and their presentation to the T-cell receptors (TCR). Co-receptor molecule CD4 enhances the binding TCR/MHC II. Small molecules that mimic surfaces of the MHC II molecule may lead to blockage of the autoimmune response and the development of drugs for immunotherapy . The HLA-DQA1~*0501/DQB1~*0201 (DQ2) and HLA-DQA1~*0501/DQB1~*0301 (DQ7) are highly correlated to autoimmune diseases as Sjogren Syndrome (SS) and Systemic Lupus Erythematosus (SLE).
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