Primary sclerosing cholangitis (PSQ is a chronic cholestatic liver disease characterized by a progressive obliterating fibrosis of the intrahepatic and extrahepatic bile ducts. The disease in symptomatic patients often progresses to secondary biliary cirrhosis, and premature death from liver failure, hepatobiliary and colon cancer1. PSC is closely associated with inflammatory bowel disease (IBD), particularly ulcerative colitis (UC), which is found in approximately two-thirds of patients with PSC of northern European origin. PSC is the most common hepatobiliary disease associated with UC. The prevalence in UC populations of PSC is between 2 and 6%. There are also associations between PSC and other immune-mediated diseases such as coeliac disease and rheumatoid arthritis.
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