INVESTIGATION OF HEMICRYPTOPHANE HOST-GUEST BINDING ENERGIES USING ADVANCED TANDEM MASS SPECTROMETRY

摘要

In advancing host-guest (H-G) chemistry, considerable effort is spent to synthesize host molecules with specific properties including selectivity and adjustable affinity. An important step in the process is the characterization of binding strengths of the H-G complexes. Here, we present a mass spectrometry based multimodal approach to obtain bond dissociation energies (BDEs) of two hemicryptophane cages with three biologically-relevant guest molecules.